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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac danger factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and sufferers should concentrate on the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which can contribute to abnormal vessel reactivity.

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However, testosterone in physiologic doses could even be beneficial in patients with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in males with established coronary artery disease . Therefore, an interaction of endogenous elements of the patient’s risk profile as nicely as the testosterone dosing may be issues of whether or not adverse events happen. Erythrocytosis has been reported as a potential effect of testosterone, which can be helpful in sufferers with anemia.

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Patients additionally may be taking concomitant stimulants, such as ephedra, which may confound data and the potential for adverse events. It is most likely going that the frequency of cardiac events is underreported within the medical literature. Moreover, testosterone has been used in the therapy of reduced muscle mass and bone density as well as anemia. The role testosterone could play within the growth of cardiovascular disease has increasingly turn out to be the subject of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embody greater than 30 pure and artificial derivatives of testosterone, may cause a large spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have observed expanded use in medical apply recently. Other frequent potential antagonistic results include infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .

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